Polymorphonuclear Neutrophils in Rheumatoid Arthritis and Systemic Lupus Erythematosus: More Complicated Than Anticipated

Polymorphonuclear neutrophils (PMN) are the most abundant leucocytes in circulation humans. They represent a heterogeneous population exerting diverse functions through several activities. Usually described as typical pro-inflammatory cells, immunomodulatory properties of PMNs have been reported. Among others, once activated and depending on stimulus, expel neutrophil extracellular traps (NET) space. NETs complexes made DNA granule proteins representing an innate immune mechanism fighting infections. Nevertheless, excess NET formation might be involved development inflammatory or autoimmune responses. Systemic lupus erythematosus (SLE) rheumatoid arthritis (RA) two chronic, inflammatory, diseases unknown etiology affecting mostly women. Several abnormal non-classical PMN sub-populations SLE RA. Particularly, suggested to trigger responses by exposing mediators. Likewise, may targets autoantibodies even autoantigens. In present review, we will summarize human discuss recent evidence linking pathogenesis both